Designing Protein-Protein Interactions - a Rosetta Commons Workshop
Elevate your skills in protein-protein interaction design and gain insights into the Nobel Prize winning AI & Biophysics-based tools shaping the future of protein engineering.
Cambridge/Boston, February 24th -26th 2025
Instructor: Amrita Nallathambi (UNC Chapel Hill, Kuhlman Group)
Course Description
Join us for an intensive, hands-on 2.5-day workshop designed for industry professionals to master the art of protein-protein interaction (PPI) design. This workshop will cover two distinct and complementary approaches: binder design (small-scale PPIs) and cage design (homo-oligomeric assemblies), providing a comprehensive exploration of the spectrum of PPI applications. Participants will learn to navigate the now "classic" protein design workflow—Diffusion for backbone generation, MPNN for sequence design, Alphafold for structure prediction, and Rosetta for final scoring and analysis—tailored to each application. These methods will showcase major variations in workflows, guiding participants in workflow design decisions, and offering practical strategies for tackling different design challenges.
Key features of the workshop include:
- Day 1: Binder Design – Focused on small, precise PPIs.
- Day 2: Cage Design – Exploring larger, more complex homo-oligomeric assemblies.
- Hands-On Team Project – Apply your learning immediately by working collaboratively to test the tools' capabilities and limitations.
This workshop is an intensive learning experience, with long hours, homework, and opportunities to delve deeply into protein design. The sessions will be recorded and shared on YouTube to benefit the broader Rosetta and protein design communities.
Who Should Attend
Professionals with a foundational understanding of protein biochemistry and basic coding skills (e.g., Python) seeking practical, advanced knowledge of modern deep learning-based protein design workflows.
Schedule
- Monday, February 24, 2025: Full day
- Tuesday, February 25, 2025: Full day
- Wednesday, February 26, 2025: Half day
Workshop Fee Schedule
This workshop is designed to complement the timing and content of Winter RosettaCon 2025, with the conference starting in the afternoon/evening of Wednesday 2/26. The workshop cost is reduced for participants who will be attending both events. To get access to the lower cost option, you must first purchase your conference registration.
- $1,800: Workshop cost with pre-paid conference registration
- $2,500: Workshop cost a la carte (not attending conference)
The appropriate workshop registration links will be shared to selected applicants
If you need help with registration please Contact Us.
For more information about Rosetta Commons please go to the Rosetta Commons Website